Article

Cryo-EM Structures of Amyloid-β Filaments With the Arctic Mutation (E22G) From Human and Mouse Brains

2022-11-07

Abstract excerpt

<h4>ABSTRACT</h4> The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case ( AβPParc1 ) with the Arctic mutation. Most filaments consist of two pairs of non-identical protofilaments that comp...

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Literature Corpus work: c486b019-8dcd-578f-acc1-277678974c2c
DOI: 10.1101/2022.11.07.515410

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