Article
High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk.
Nature genetics - 1 Aug 2026
Malysheva Valeriya, Ray-Jones Helen, Lakes Nora, Brown Rachel A, Cazares Tareian A, Clay Owen, Ohayon David E, Artemov Pavel, Wayman Joseph A, Yang Zi F, Della Rosa Monica, Petitjean Carmen, Booth Clarissa, Ellaway Joseph I J, Barnes Jenna R, Dangel Andrew W, Saini Ankita, Orchard William R, Chen Xiaoting, Parameswaran Sreeja, Burden Frances, Frontini Mattia, Nagano Takashi, Fraser Peter, Schoenfelder Stefan, Weirauch Matthew T, Kottyan Leah C, Smith David F, Powell Nick, Weimer Jill M, Oltz Eugene M, Wallace Chris, Miraldi Emily R, Waggoner Stephen N, Spivakov Mikhail
Abstract excerpt
Innate lymphoid cells (ILCs) are rare tissue-resident lymphocytes that functionally mirror cells of CD4+ T helper lineage but lack antigen receptors. Type 3 ILCs (ILC3s) are enriched at barrier sites, regulating inflammation and promoting tissue integrity. Here we profile the promoter-anchored chromosomal contacts of primary human ILC3s using low-input, high-resolution targeted chromosome conformation capture and...
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