Article

Human ILC methylomes uncover stable lineage codes and disease-linked ILC2 regulators in allergy

2026-03-14

Abstract excerpt

The transcriptional programs of human ILCs are increasingly defined, but the DNA-methylation landscapes that stabilize their identity and function remain poorly understood. Here, we generated genome-wide DNA methylomes of human NK cells, ILC1, ILC2, and ILC3 from blood and lymphoid tissues. Subset-specific differentially methylated regions distinguished all populations and mapped to canonical regulators, including...

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Literature Corpus work: 1b762fc9-cdbb-5ea2-b4f9-c205246c92d9
DOI: 10.64898/2026.03.12.711290

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