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Article

Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility.

The Journal of allergy and clinical immunology - 1 Dec 2018

Stadhouders Ralph, Li Bobby W S, de Bruijn Marjolein J W, Gomez Antonio, Rao Tata Nageswara, Fehling Hans Jörg, van IJcken Wilfred F J, Lim Ai Ing, Di Santo James P, Graf Thomas, Hendriks Rudi W

Abstract excerpt

BACKGROUND: Group 2 innate lymphoid cells (ILC2s) are major producers of the cytokines driving allergic asthma, and increased ILC2 numbers have been detected in blood and sputum of asthmatic patients. Asthma susceptibility has a strong genetic component, but the underlying mechanisms and whether asthma genetics affect ILC2 biology remain unclear. OBJECTIVE: We sought to study the ILC2 transcriptome and epigenome...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

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Source

Identifiers

PMID: 29486229
DOI: 10.1016/j.jaci.2017.12.1006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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