Article
Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility.
The Journal of allergy and clinical immunology - 1 Dec 2018
Stadhouders Ralph, Li Bobby W S, de Bruijn Marjolein J W, Gomez Antonio, Rao Tata Nageswara, Fehling Hans Jörg, van IJcken Wilfred F J, Lim Ai Ing, Di Santo James P, Graf Thomas, Hendriks Rudi W
Abstract excerpt
BACKGROUND: Group 2 innate lymphoid cells (ILC2s) are major producers of the cytokines driving allergic asthma, and increased ILC2 numbers have been detected in blood and sputum of asthmatic patients. Asthma susceptibility has a strong genetic component, but the underlying mechanisms and whether asthma genetics affect ILC2 biology remain unclear. OBJECTIVE: We sought to study the ILC2 transcriptome and epigenome...
Topics
- Animals
- Asthma
- Epigenesis, Genetic
- GATA3 Transcription Factor
- Genetic Predisposition to Disease
- Genome
- Humans
- Immunity, Innate
- Lymphocytes
- Mice
- Regulatory Sequences, Nucleic Acid
- Transcriptome