Article

Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn’s disease

2024-12-11

Abstract excerpt

Crohn’s disease (CD) is a complex inflammatory bowel disease resulting from an interplay of genetic, microbial, and environmental factors. Cell-type-specific contributions to CD etiology and genetic risk are incompletely understood. Here we built a comprehensive atlas of cell-type- resolved chromatin accessibility comprising 557,310 candidate cis-regulatory elements (cCREs) in terminal ileum and ascending colon fr...

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Literature Corpus work: 8783903e-fe89-5aa5-a301-db32f56c0595
DOI: 10.1101/2024.12.10.24318718

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