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Article

Large-Scale Analyses of GWAS Identify Five Key Pleiotropic Genes Involved in Complex Diseases.

Genes - 30 Jun 2026

Mahdi Imene, Chabchoub Ghazi, Kharrat Najla, Rebai Ahmed

Abstract excerpt

Background/Objectives: Genome-Wide Association Studies (GWASs) have revealed numerous Single Nucleotide Polymorphisms (SNPs) linked to diverse diseases and traits, highlighting extensive pleiotropy. This study aimed to identify functionally relevant pleiotropic genes through large-scale analysis of the GWAS catalog and variant annotation. Methods: An initial set of 494 putative pleiotropic genes across 223...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42510806
DOI: 10.3390/genes17070766
PMCID: PMC13409521

Genes

ABO
ALDH2
GCKR
TERT

Variants

rs671
rs1260326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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