Article

A global overview of pleiotropy and genetic architecture in complex traits

2018-12-19

Abstract excerpt

<h4>ABSTRACT</h4> After a decade of genome-wide association studies (GWASs), fundamental questions in human genetics are still unanswered, such as the extent of pleiotropy across the genome, the nature of trait-associated genetic variants and the disparate genetic architecture across human traits. The current availability of hundreds of GWAS results provide the unique opportunity to gain insight into these questi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be62bd52-b3e8-5407-9a63-15d9ab7696e0
DOI: 10.1101/500090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A global overview of pleiotropy and genetic architecture in complex traitsDOI 10.1101/500090Read

Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants.Semantic proximity Read

Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global BiobanksSemantic proximity Read

Mapping Genetic Architecture of Thousands of Complex Traits Using GWAS Summary StatisticsSemantic proximity Read

A plethora of pleiotropy across complex traits.Semantic proximity Read

Inferring genetic variant networks by leveraging pleiotropy shows trait relationships drive massive pleiotropy in GWASSemantic proximity Read

Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits.Semantic proximity Read

Phenome-wide search for pleiotropic loci highlights key genes and molecular pathways for human complex traitsSemantic proximity Read

Genetic pleiotropy in complex traits and diseases: implications for genomic medicine.Semantic proximity Read

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease MechanismsSemantic proximity Read

Dissecting pleiotropy to gain mechanistic insights into human disease.Semantic proximity Read

Phenotype-specific enrichment of Mendelian disorder genes near GWAS regions across 62 complex traitsSemantic proximity Read

Pleiotropy in complex traits: challenges and strategies.Semantic proximity Read