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Article

Abundant pleiotropy in human complex diseases and traits.

American journal of human genetics - 11 Nov 2011

Sivakumaran Shanya, Agakov Felix, Theodoratou Evropi, Prendergast James G, Zgaga Lina, Manolio Teri, Rudan Igor, McKeigue Paul, Wilson James F, Campbell Harry

Abstract excerpt

We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits. We find abundant evidence of pleiotropy; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects. SNP pleiotropic status was associated with gene location (p = 0.024; pleiotropic SNPs more often exonic [14.5% versus 4.9% for nonpleiotropic, trait-associated...

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Source

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Identifiers

PMID: 22077970
DOI: 10.1016/j.ajhg.2011.10.004
PMCID: PMC3213397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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