Large-scale pleiotropic analysis across cancers reveals shared genetic mechanisms and identifies novel functional genes.

Abstract excerpt

Pleiotropic genetic loci have been increasingly reported in cancer, and identifying genetic variants with pleiotropic associations can reveal shared biological pathways influencing multiple cancers. Using summary statistics from genome-wide association studies for 37 cancer types (N = 433 836), we identified extensive genome-wide and local genetic correlations among cancers. Through pairwise pleiotropic analysis,...

Topics

• Humans
• Neoplasms
• Polymorphism, Single Nucleotide
• Genetic Pleiotropy
• Genome-Wide Association Study
• Genetic Predisposition to Disease