Article
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.
Nature genetics - 1 Jul 2021
Veturi Yogasudha, Lucas Anastasia, Bradford Yuki, Hui Daniel, Dudek Scott, Theusch Elizabeth, Verma Anurag, Miller Jason E, Kullo Iftikhar, Hakonarson Hakon, Sleiman Patrick, Schaid Daniel, Stein Charles M, Edwards Digna R Velez, Feng QiPing, Wei Wei-Qi, Medina Marisa W, Krauss Ronald M, Hoffmann Thomas J, Risch Neil, Voight Benjamin F, Rader Daniel J, Ritchie Marylyn D
Abstract excerpt
Plasma lipids are known heritable risk factors for cardiovascular disease, but increasing evidence also supports shared genetics with diseases of other organ systems. We devised a comprehensive three-phase framework to identify new lipid-associated genes and study the relationships among lipids, genotypes, gene expression and hundreds of complex human diseases from the Electronic Medical Records and Genomics (347...
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