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Article

Multi-omics uncovers the pleiotropic genetic mechanisms linking MASLD and cardiometabolic syndromes.

Cardiovascular diabetology - 9 May 2026

Yin Kangjia, Zhang Cao, Liu Bing, Xu Ruyun, Zeng Jing, Eslam Mohammed, Ni Jing

Abstract excerpt

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular-kidney-metabolic (CKM) syndrome are interrelated conditions with shared pathophysiological features; however, the genetic architecture underlying their relationship has not been fully elucidated. Deciphering this shared genetic basis holds promise for advancing mechanistic insights and therapeutic discovery. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42106791
DOI: 10.1186/s12933-026-03180-6
PMCID: PMC13326089

Genes

CKM
APOE
FTO
GPBAR1
LPL
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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