Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2026

Yang Neil V, Wang Shaowei, Li Boyang, Simms Jeffrey, Dinh Linsey, Huang Annie, Oei Jacob H, Yassine Hussein N, Krauss Ronald M

Abstract excerpt

INTRODUCTION: While the apolipoprotein E (APOE) ε4 allele is a major risk factor for Alzheimer's disease (AD), the role of translocase of outer mitochondrial membrane 40 (TOMM40)-an adjacent gene involved in mitochondrial protein import-is not known. METHODS: Human brain tissue, human induced pluripotent stem cell-derived neurons (iNeurons), and mice were used for study of gene expression, cholesterol metabolism,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol

Share to Induced Pluripotent Stem Cells

Share to Membrane Transport Proteins

Share to Mitochondria

Share to Mitochondrial Precursor Protein Import Complex Proteins

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 41954048
DOI: 10.1002/alz.71306
PMCID: PMC13063120

Genes

TOMM40
APOE
LDLR
NR1H2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease.PMID 41954048Read ↗

<i>TOMM40</i> suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s diseaseSemantic proximity Read ↗

TOMM40-APOE chimera linking Alzheimer’s highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesisSemantic proximity Read ↗

ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.Semantic proximity Read ↗

TOMM40 RNA Transcription in Alzheimer’s Disease Brain and Its Implication in Mitochondrial DysfunctionSemantic proximity Read ↗

Regulatory roles of microRNAs in modulating mitochondrial dynamics, amyloid beta fibrillation, microglial activation, and cholinergic signaling: Implications for alzheimer's disease pathogenesisSemantic proximity Read ↗

An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegenerationSemantic proximity Read ↗

Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathwaysSemantic proximity Read ↗

TOMM40 and APOE variants synergistically increase the risk of Alzheimer's disease in a Chinese population.Semantic proximity Read ↗

Therapeutic considerations for APOE and TOMM40 in Alzheimers disease: A tribute to Allen Roses MD.Semantic proximity Read ↗

TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease.Semantic proximity Read ↗

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological EffectsSemantic proximity Read ↗

TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.