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Article

5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.

Human molecular genetics - 15 Jun 2016

Bernstein Alison I, Lin Yunting, Street R Craig, Lin Li, Dai Qing, Yu Li, Bao Han, Gearing Marla, Lah James J, Nelson Peter T, He Chuan, Levey Allan I, Mullé Jennifer G, Duan Ranhui, Jin Peng

Abstract excerpt

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognitive function. Pathogenesis of AD is incompletely understood; evidence suggests a role for epigenetic regulation, in particular the cytosine modifications 5-methylcytosine and 5-hydroxymethylcytosine (5hmC). 5hmC is enriched in the nervous system and displays neurodevelopment and age-related...

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Identifiers

PMID: 27060332
DOI: 10.1093/hmg/ddw109
PMCID: PMC5181627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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