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Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways

14 Jul 2022

Abstract excerpt

Alzheimers disease (AD) is the main cause of dementia and it is defined by cognitive decline coupled to extracellular deposit of amyloid-beta protein and intracellular hyperphosphorylation of tau protein. Historically, efforts to target such hallmarks have failed in numerous clinical trials. In addition to these hallmark-targeted approaches, several clinical trials focus on other AD pathological processes, such...

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PMID: 35839870
DOI: 10.1016/j.bbamcr.2022.119326

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