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The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression.

Neurobiology of disease - 1 Mar 2023

Corsi Giulia I, Gadekar Veerendra P, Haukedal Henriette, Doncheva Nadezhda T, Anthon Christian, Ambardar Sheetal, Palakodeti Dasaradhi, Hyttel Poul, Freude Kristine, Seemann Stefan E, Gorodkin Jan

Abstract excerpt

Alzheimer's disease (AD) is a progressive and irreversible brain disorder, which can occur either sporadically, due to a complex combination of environmental, genetic, and epigenetic factors, or because of rare genetic variants in specific genes (familial AD, or fAD). A key hallmark of AD is the accumulation of amyloid beta (Aβ) and Tau hyperphosphorylated tangles in the brain, but the underlying pathomechanisms...

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PMID: 36572121
DOI: 10.1016/j.nbd.2022.105980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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