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<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers’s disease

2025-05-09

Abstract excerpt

Among the more than 90 identified genetic risk loci for late-onset Alzheimer’s disease (AD) and related dementias, the apolipoprotein E gene ( APOE ) ɛ2/ɛ3/ɛ4 polymorphisms remains the longstanding benchmark for genetic disease risk with a consistently large effect across studies 1–10 . Despite this massive signal, the exact mechanisms for how ɛ4 increases and for how ɛ2 decreases dementia risk is not well-under...

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Literature Corpus work
e4819f6c-6b85-50ac-b6d5-ae4837291e49
DOI
10.1101/2025.05.07.25327065
Open publication

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<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers’s diseaseDOI 10.1101/2025.05.07.25327065
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