Article

Integrative Genetic, Proteogenomic, and Multi-omics Analyses Reveal Sex-Biased Causal Genes and Drug Targets in Alzheimer’s Disease

2025-11-02

Abstract excerpt

Sex differences are pervasive in Alzheimer’s disease, but the underlying drivers remain poorly understood. To address this, we performed sex-stratified genome-wide association studies of Alzheimer’s disease in ∼1,000,000 individuals, which we subsequently integrated with proteogenomics datasets from neurological tissues to identify candidate causal genes. We further prioritized genes through additional multi-omics...

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Literature Corpus work: 1dabe80b-8112-5acb-8121-bb55dbf2e707
DOI: 10.1101/2025.10.31.25339089

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