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Article

Microglial PICALM: A novel genetic driver and therapeutic target in vascular dementia.

Archives of gerontology and geriatrics - 1 Nov 2026

Chai Zhaohui, Xu Qiuhan, Cheng Dan, Zhang Yuning, Liu Zongchi, Wang Liyun, Yang Jiqi, Li Hongyu, Gu Jun, Liu Wenchao, Zheng Jiesheng, Gong Jiangbiao, Zhu Yu, Shen Jian

Abstract excerpt

BACKGROUND: Vascular dementia (VaD) lacks well-defined genetic mechanisms. Cell-type-specific effects of GWAS loci remain unexplored. METHODS: We integrated single‑cell eQTL data (183 donors, eight cell types) with VaD GWAS (3624 cases, 475,484 controls) using Mendelian randomization and Bayesian colocalization, replicated in an independent cohort (2074 cases, 456,366 controls). Subtype, snRNA‑seq, cell‑cell...

Read the complete abstract on PubMed

Topics

Humans
Dementia, Vascular
Microglia
Genome-Wide Association Study
Male
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Aged

Mendelian Randomization Analysis

Genetic Predisposition to Disease

Drug Repositioning

Source

Identifiers

PMID: 42250393
DOI: 10.1016/j.archger.2026.106324

Genes

PICALM
GAS6
GRN
SPP1

Provenance

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