Mapping the Neurovascular Unit Genetic Architecture of Early-Onset Ischemic Stroke: A Single-Cell Causal Framework for Target Discovery and Therapeutic Translation.

Abstract excerpt

BACKGROUND: The global incidence of early-onset ischemic stroke (EOS) is rising, with younger patients showing marked heterogeneity and lacking traditional risk factors, underscoring the role of undiscovered genetic determinants. The neurovascular unit (NVU) is central to cerebral homeostasis, yet whether its functional alterations contribute to ischemic stroke susceptibility remains unclear. Defining the NVU’s...

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