Article

Single-cell multi-region dissection of brain vasculature in Alzheimer’s Disease

2022-02-10

Abstract excerpt

Cerebrovascular breakdown occurs early in Alzheimer’s Disease (AD), but its cell-type-specific molecular basis remains uncharacterized. Here, we characterize single-cell transcriptomic differences in human cerebrovasculature across 220 AD and 208 control individuals and across 6 brain regions. We annotate 22,514 cerebrovascular cells in 11 subtypes of endothelial, pericyte, smooth muscle, perivascular fibroblast,...

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Literature Corpus work: 30c2e3cd-ccf6-58c6-8bc0-0eb0732b2ce0
DOI: 10.1101/2022.02.09.479797

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