Article

Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair

2024-03-27

Abstract excerpt

Vascular dementia (VaD) is a white matter ischemic disease and the second-leading cause of dementia, with no direct therapy. Within the lesion site, cell-cell interactions dictate the trajectory towards disease progression or repair. To elucidate the underlying intercellular signaling pathways, a VaD mouse model was developed for transcriptomic and functional studies. The mouse VaD transcriptome was integrated wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 142bbc90-5d18-5316-92f6-f4d51305958e
DOI: 10.1101/2024.03.24.585301

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia RepairDOI 10.1101/2024.03.24.585301Read

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profilingSemantic proximity Read

Single-cell multi-region dissection of brain vasculature in Alzheimer’s DiseaseSemantic proximity Read

Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular DementiaSemantic proximity Read

Identification of Molecular Signatures and Candidate Drugs in Vascular Dementia by Bioinformatics AnalysesSemantic proximity Read

Shared and disease-specific human brain vascular signatures in Alzheimer’s disease, frontotemporal dementia, and Huntington’s diseaseSemantic proximity Read

Secondary single-cell transcriptomic analysis reveals common molecular signatures of cerebrovascular injury between traumatic brain injury and agingSemantic proximity Read

Transcriptomic Evidence of MAS1 Receptor Dysregulation and a Failed Compensatory State in Human Vascular Cognitive ImpairmentSemantic proximity Read

Single Nuclei Transcriptome Reveals Perturbed Brain Vascular Molecules in Alzheimer’s DiseaseSemantic proximity Read

Genome-wide cross-trait analysis of vascular dementia and Alzheimer’s disease highlights novel loci and lung-brain axisSemantic proximity Read

ITGB5 is highly expressed in ischemic stroke and cerebrovascular dementia to induce disease progressionSemantic proximity Read

Multimodal analysis identifies pericyte-centered signaling programs altered by sex and brain region in Alzheimer’s DiseaseSemantic proximity Read

Systematic analysis of cellular crosstalk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s diseaseSemantic proximity Read