Article

PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer’s Disease

2025-02-25

Abstract excerpt

Alzheimer’s disease (AD) is marked by the coordinated emergence of disease-associated cell states across multiple cell types. Here, we first performed a meta-analysis of single-nucleus transcriptomic (snRNAseq) data from 869 brains of diverse decedents, confirming the critical role of an SLC38A2 high SMTN high CACNA1D high astrocyte subset, Astrocyte 10 (Ast10), in AD and aging-related cognitive decline. We th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5899ccb2-c579-505b-a4b2-c09c5aae0745
DOI: 10.1101/2025.02.24.639868

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer’s DiseaseDOI 10.1101/2025.02.24.639868Read

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathologySemantic proximity Read

A landscape of the genetic and cellular heterogeneity in Alzheimer diseaseSemantic proximity Read

Human microglia show unique transcriptional changes in Alzheimer’s diseaseSemantic proximity Read

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseaseSemantic proximity Read

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypesSemantic proximity Read

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and agingSemantic proximity Read

Functional Specificity of Astrocyte Subtypes in Alzheimer’s Disease: Decoding Disease Mechanisms Through Network-based Analysis of Integrated Single-Nuclei Multi-Omic DataSemantic proximity Read

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tanglesSemantic proximity Read

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathologySemantic proximity Read

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read