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Article

Subtype-Specific Alterations in Copper Trafficking Associated with KRAS Mutations in Isogenic Colorectal Cancer Cell Lines.

Biological trace element research - 1 Sept 2026

Üveges Elina, Gaál Anikó, Szakács Gergely, Bakos Éva, Streli Christina, Kregsamer Peter, Baranyi Marcell, Hegedűs Balázs, Szoboszlai Norbert

Abstract excerpt

Copper bioavailability has been identified as a potential target for KRAS-mutant colorectal cancer, a disease for which treatment options remain limited. Therefore, we investigated copper homeostasis in isogeneic colorectal cancer cell models carrying distinct KRAS codon 12 mutations (G12C, G12D and G12V). Our results show that copper homeostasis differs among KRAS-mutant cells in a mutation-specific manner, with...

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Identifiers

PMID: 42230420
DOI: 10.1007/s12011-026-05171-w
PMCID: PMC13437747

Genes

KRAS
ATP7A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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