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Article

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.

Nature communications - 24 Jul 2020

Aubert Léo, Nandagopal Neethi, Steinhart Zachary, Lavoie Geneviève, Nourreddine Sami, Berman Jacob, Saba-El-Leil Marc K, Papadopoli David, Lin Sichun, Hart Traver, Macleod Graham, Topisirovic Ivan, Gaboury Louis, Fahrni Christoph J, Schramek Daniel, Meloche Sylvain, Angers Stephane, Roux Philippe P

Abstract excerpt

Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic KRAS has been extremely challenging to target therapeutically. To identify potential vulnerabilities in KRAS-mutated CRC, we characterize the impact of oncogenic KRAS on the cell surface of intestinal epithelial cells. Here we show that oncogenic KRAS alters the expression of a myriad of cell-surface proteins implicated in...

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Identifiers

PMID: 32709883
DOI: 10.1038/s41467-020-17549-y
PMCID: PMC7381612

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