Article
Targeting ATP7A-Dependent Copper Metabolic Homeostasis Induces Cuproptosis and Suppresses the Progression of Mutant KRAS-Driven Lung Cancer.
Cancer research - 15 Oct 2025
Zhao Jian, Zhang Weijie, Zeng Yuanyuan, Lu Di, Ma Chenkang, Zhang Mengzhu, Cai Xin, Huang Zhifan, Yang Hongli, Li Jianjun, Zhu Jianjie, Huang Jian-An, Liu Zeyi
Abstract excerpt
Despite progress in tumor-targeted therapy, oncogenic KRAS remains a major challenge in treating lung adenocarcinoma. In clinical practice, KRASG12C inhibitors have limited response rates and are associated with acquired drug resistance. Cuproptosis is a recently identified form of copper (Cu)-mediated cell death, and previous studies have revealed that Cu metabolism plays an important role in the development of...
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