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Metabonomics study of the effects of single copy mutant KRAS in the presence or absence of WT allele using human HCT116 isogenic cell lines.

Metabolomics : Official journal of the Metabolomic Society - 25 Nov 2021

Varshavi Dorna, Varshavi Dorsa, McCarthy Nicola, Veselkov Kirill, Keun Hector C, Everett Jeremy R

Abstract excerpt

INTRODUCTION: KRAS was one of the earliest human oncogenes to be described and is one of the most commonly mutated genes in different human cancers, including colorectal cancer. Despite KRAS mutants being known driver mutations, KRAS has proved difficult to target therapeutically, necessitating a comprehensive understanding of the molecular mechanisms underlying KRAS-driven cellular transformation. OBJECTIVES: To...

Topics

Alleles
Cell Line
Colorectal Neoplasms
Humans
Metabolomics
Proto-Oncogene Proteins p21(ras)

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34822010
DOI: 10.1007/s11306-021-01852-w
PMCID: PMC8616861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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