Impact of Oncogenic Changes in p53 and KRAS on Macropinocytosis and Ferroptosis in Colon Cancer Cells and Anticancer Efficacy of Niclosamide with Differential Effects on These Two Processes.

doi:10.3390/cells13110951

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Article

Impact of Oncogenic Changes in p53 and KRAS on Macropinocytosis and Ferroptosis in Colon Cancer Cells and Anticancer Efficacy of Niclosamide with Differential Effects on These Two Processes.

Cells - 30 May 2024

Nguyen Nhi T, Sennoune Souad R, Dharmalingam-Nandagopal Gunadharini, Sivaprakasam Sathish, Bhutia Yangzom D, Ganapathy Vadivel

Abstract excerpt

Mutations in p53 and KRAS are seen in most cases of colon cancer. The impact of these mutations on signaling pathways related to cancer growth has been studied in depth, but relatively less is known on their effects on amino acid transporters in cancer cells. This represents a significant knowledge gap because amino acid nutrition in cancer cells profoundly influences macropinocytosis and ferroptosis, two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38891084
DOI: 10.3390/cells13110951
PMCID: PMC11171492

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