Article

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

2023-03-01

Abstract excerpt

Aberrant tumor metabolism is a hallmark of cancer in which metabolic rewiring can support tumor growth under nutrient deficient conditions. KRAS mutations occur in 35-45% of all colorectal cancer (CRC) cases and are difficult to treat. The relationship between mutant KRAS and aberrant metabolism in CRCs has not been fully explored and could be a target for intervention. We previously acquired non-targeted metabolo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f96d93d6-a5cd-5842-bf8e-49efc8c676dc
DOI: 10.1101/2023.02.28.530478

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutationsDOI 10.1101/2023.02.28.530478Read

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutationsSemantic proximity Read

A machine learning and drug repurposing approach to target ferroptosis in colorectal cancer stratified by sex and KRASSemantic proximity Read

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expressionSemantic proximity Read

Gut Microbiome Mediates Ferroptosis Resistance for Colorectal Cancer DevelopmentSemantic proximity Read

Targeting HIF-2α in Colorectal Cancer Reveals a Cholesterol Biosynthesis–Dependent Ferroptotic VulnerabilitySemantic proximity Read

EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer.Semantic proximity Read

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis.Semantic proximity Read

Patient-Specific Pharmacogenomics unveils xCT as a Key Regulator for Druggable Metabolic and Proliferation Pathways in Colon CancerSemantic proximity Read

ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosisSemantic proximity Read

SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma.Semantic proximity Read

Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells.Semantic proximity Read

Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosisSemantic proximity Read