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Article

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer.

EMBO reports - 1 Jan 2026

Ber Suzan, Yang Ming, Sciacovelli Marco, Samarajiwa Shamith, Patel Khushali, Nikitopoulou Efterpi, Howitt Annie, Cook Simon J, Venkitaraman Ashok R, Frezza Christian, Esposito Alessandro

Abstract excerpt

Mutations in KRAS, particularly at codon 12, are frequent in adenocarcinomas of the colon, lungs and pancreas, driving carcinogenesis by altering cell signalling and reprogramming metabolism. However, the specific mechanisms by which different KRAS G12 alleles initiate distinctive patterns of metabolic reprogramming are unclear. Using isogenic panels of colorectal cell lines harbouring the G12A, G12C, G12D and...

Topics

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Cell Line, Tumor
Colorectal Neoplasms
Forkhead Box Protein O1
Gene Expression Regulation, Neoplastic
Glutamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 41266617
DOI: 10.1038/s44319-025-00641-z
PMCID: PMC12795846

Genes

KRAS
FOXO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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