Differential reprogramming of isogenic colorectal cancer cells by distinct activating KRAS mutations.

Abstract excerpt

Oncogenic mutations of Ras at codons 12, 13, or 61, that render the protein constitutively active, are found in ∼ 16% of all cancer cases. Among the three major Ras isoforms, KRAS is the most frequently mutated isoform in cancer. Each Ras isoform and tumor type displays a distinct pattern of codon-specific mutations. In colon cancer, KRAS is typically mutated at codon 12, but a significant fraction of patients...

Topics

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• Cell Line, Tumor
• Colorectal Neoplasms
• Genes, ras
• Intracellular Signaling Peptides and Proteins
• Mutation