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Article

Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines.

World journal of gastroenterology - 28 Apr 2016

Chandhok Gursimran, Horvath Judit, Aggarwal Annu, Bhatt Mohit, Zibert Andree, Schmidt Hartmut Hj

Abstract excerpt

AIM: To study the effect of anti-copper treatment for survival of hepatic cells expressing different ATP7B mutations in cell culture. METHODS: The most common Wilson disease (WD) mutations p.H1069Q, p.R778L and p.C271*, found in the ATP7B gene encoding a liver copper transporter, were studied. The mutations represent major genotypes of the United States and Europe, China, and India, respectively. A human hepatoma...

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Identifiers

PMID: 27122662
DOI: 10.3748/wjg.v22.i16.4109
PMCID: PMC4837429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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