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Article

Identification of regulators of the three-dimensional polycomb organization by a microscopy-based genome-wide RNAi screen.

Molecular cell - 8 May 2014

Gonzalez Inma, Mateos-Langerak Julio, Thomas Aubin, Cheutin Thierry, Cavalli Giacomo

Abstract excerpt

Polycomb group (PcG) proteins dynamically define cellular identities through epigenetic repression of key developmental genes. PcG target gene repression can be stabilized through the interaction in the nucleus at PcG foci. Here, we report the results of a high-resolution microscopy genome-wide RNAi screen that identifies 129 genes that regulate the nuclear organization of Pc foci. Candidate genes include PcG...

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Identifiers

PMID: 24703951
DOI: 10.1016/j.molcel.2014.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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