Article
MAK-2 Kinase Is Required for Extended Longevity and Enhanced Stress Resistance Resulting From Mild Impairment of Mitochondrial Function in isp-1 Mutants.
Aging cell - 1 May 2026
Anglas Ulrich, Alokda Abdelrahman, Zhu Shusen, González Aura A Tamez, Celtikcioglu Ekin, Guan Jiaxi, Promi Maisha M, Booth Grant F, Pacis Alain, Van Raamsdonk Jeremy M
Abstract excerpt
Although mitochondrial function is essential for life in multicellular organisms, work from multiple model organisms has demonstrated that a mild impairment of mitochondrial function can increase lifespan. In C. elegans, a mutation in the isp-1 gene, which encodes the Rieske iron sulfur protein in Complex III of the mitochondrial electron transport chain, results in increased lifespan, enhanced resistance to...
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