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Article

C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.

PloS one - 1 Jan 2016

Shen Yanqing, Ng Li Fang, Low Natarie Pei Wen, Hagen Thilo, Gruber Jan, Inoue Takao

Abstract excerpt

Mitochondria play a critical role in aging, however, the underlying mechanism is not well understood. We found that a mutation disrupting the C. elegans homolog of Miro GTPase (miro-1) extends life span. This phenotype requires simultaneous loss of miro-1 from multiple tissues including muscles and neurons, and is dependent on daf-16/FOXO. Notably, the amount of mitochondria in the miro-1 mutant is reduced to...

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PMID: 27064409
DOI: 10.1371/journal.pone.0153233
PMCID: PMC4827821

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Source receipt: pubmed, retrieved 7 Sept 2026.

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