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Article

CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.

PLoS genetics - 1 Feb 2014

Baruah Aiswarya, Chang Hsinwen, Hall Mathew, Yuan Jie, Gordon Sarah, Johnson Erik, Shtessel Ludmila L, Yee Callista, Hekimi Siegfried, Derry W Brent, Lee Siu Sylvia

Abstract excerpt

Caenorhabditis elegans CEP-1 and its mammalian homolog p53 are critical for responding to diverse stress signals. In this study, we found that cep-1 inactivation suppressed the prolonged lifespan of electron transport chain (ETC) mutants, such as isp-1 and nuo-6, but rescued the shortened lifespan of other ETC mutants, such as mev-1 and gas-1. We compared the CEP-1-regulated transcriptional profiles of the...

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PMID: 24586177
DOI: 10.1371/journal.pgen.1004097
PMCID: PMC3937132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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