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Article

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.

PLoS genetics - 1 Jul 2016

Munkácsy Erin, Khan Maruf H, Lane Rebecca K, Borror Megan B, Park Jae H, Bokov Alex F, Fisher Alfred L, Link Christopher D, Rea Shane L

Abstract excerpt

Mitochondrial dysfunction underlies numerous age-related pathologies. In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be alleviated, we examined how the nematode C. elegans not only adapts to disruption of the mitochondrial electron transport chain, but in many instances responds with extended lifespan. Studies have shown various retrograde responses are activated in these...

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Identifiers

PMID: 27420916
DOI: 10.1371/journal.pgen.1006133
PMCID: PMC4946786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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