Article

Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunity

2021-04-01

Abstract excerpt

While mitochondrial function is essential for life in all multicellular organisms, a mild impairment of mitochondrial function can extend longevity. By understanding the molecular mechanisms involved, these pathways might be targeted to promote healthy aging. In studying two long-lived mitochondrial mutants in C. elegans, we found that disrupting subunits of the mitochondrial electron transport chain resulted in...

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Literature Corpus work: 41c33db0-92d1-5073-ad9a-332dc24f350c
DOI: 10.1101/2021.03.31.437812

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