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Article

Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant.

PloS one - 1 Jan 2013

Pujol Claire, Bratic-Hench Ivana, Sumakovic Marija, Hench Jürgen, Mourier Arnaud, Baumann Linda, Pavlenko Victor, Trifunovic Aleksandra

Abstract excerpt

Many Caenorhabditis elegans mutants with dysfunctional mitochondrial electron transport chain are surprisingly long lived. Both short-lived (gas-1(fc21)) and long-lived (nuo-6(qm200)) mutants of mitochondrial complex I have been identified. However, it is not clear what are the pathways determining the difference in longevity. We show that even in a short-lived gas-1(fc21) mutant, many longevity assurance...

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Identifiers

PMID: 23555681
DOI: 10.1371/journal.pone.0059493
PMCID: PMC3610896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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