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Article

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.

Free radical biology & medicine - 1 Jul 2017

Dues Dylan J, Schaar Claire E, Johnson Benjamin K, Bowman Megan J, Winn Mary E, Senchuk Megan M, Van Raamsdonk Jeremy M

Abstract excerpt

Mutations affecting components of the mitochondrial electron transport chain have been shown to increase lifespan in multiple species including the worm Caenorhabditis elegans. While it was originally proposed that decreased generation of reactive oxygen species (ROS) resulting from lower rates of electron transport could account for the observed increase in lifespan, recent evidence indicates that ROS levels are...

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PMID: 28392283
DOI: 10.1016/j.freeradbiomed.2017.04.004
PMCID: PMC5493208

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