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Article

The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans.

Mechanisms of ageing and development - 1 Jun 2004

Kayser Ernst-Bernhard, Sedensky Margaret M, Morgan Phil G

Abstract excerpt

A mutation in a subunit of complex I of the mitochondrial electron transport chain (gas-1) causes Caenorhabditis elegans to be hypersensitive to volatile anesthetics and oxygen as well as shortening lifespan. We hypothesized that changes in mitochondrial respiration or reactive oxygen species production cause these changes. Therefore, we compared gas-1 to other mitochondrial mutants to identify the relative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15178135
DOI: 10.1016/j.mad.2004.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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