Article
PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity.
The Journal of experimental medicine - 1 Jun 2026
Liu Shibo, Liang Guanghao, Yang Yayun, Shi Yanyang, Dong Lihui, Zhao Yue, Mei Boyuan, Wang Jun, Lin Feng, Li Yilin, Dong Wenxin, Liu Chengyang, Cao Yuhui, Han Dali, Chen Peng R, Xu Meng Michelle
Abstract excerpt
Linking T cell phenotypes with antigen specificity and functional avidity is critical for understanding in vivo immune responses in infection and cancer. Here, we develop PRECISE-seq, a method that integrates multi-omics T cell analysis with contact-dependent proximity labeling for rapid screening of disease-relevant T cell repertoires, and for linking the relative TCR avidity with T cell phenotypes at...
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