Article

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy response

2026-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Tumor-specific exhausted CD8 T cells (Tex) adopt diverse phenotypes across human cancers, but the drivers of this heterogeneity remain poorly understood. Using flow cytometry and single-cell RNA and T cell receptor (TCR) sequencing of 106,667 tumor-infiltrating CD8 T cells from head and neck squamous cell carcinoma (HNSCC) tumors, we identified and validated three Tex subsets, each with distinct...

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Literature Corpus work: 6e044d5c-27e2-591e-bb0a-b00aa68131b0
DOI: 10.64898/2026.05.29.728765

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