Article
In-depth analysis of human virus-specific CD8+ T cells delineates unique phenotypic signatures for T cell specificity prediction.
Cell reports - 31 Oct 2023
Schmidt Florian, Fields Hannah F, Purwanti Yovita, Milojkovic Ana, Salim Syazwani, Wu Kan Xing, Simoni Yannick, Vitiello Antonella, MacLeod Daniel T, Nardin Alessandra, Newell Evan W, Fink Katja, Wilm Andreas, Fehlings Michael
Abstract excerpt
Following viral infection, the human immune system generates CD8+ T cell responses to virus antigens that differ in specificity, abundance, and phenotype. A characterization of virus-specific T cell responses allows one to assess infection history and to understand its contribution to protective immunity. Here, we perform in-depth profiling of CD8+ T cells binding to CMV-, EBV-, influenza-, and SARS-CoV-2-derived...
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