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Article

Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancer

23 Mar 2023

Abstract excerpt

Exhausted T (TEX) cells are main immunotherapy targets in cancer, but it lacks a general identification method to characterize TEX cell in disease. To assess the characterization of TEX cell, we extract signature of TEX cell from large cancer and chronic infection cohorts. Based on single-cell transcriptomes, a systematic T cell exhaustion prediction (TEXP) model is designed to define TEX cell in cancer and...

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PMID: 37091230
DOI: 10.1016/j.isci.2023.106484

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