Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.

doi:10.1158/1055-9965.EPI-26-0156

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Article

Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2026

Meng Xiaoxi, Chen Cheng, Qin Na, Mulder Heather L, Easton John, Edmonson Michael N, Rusch Michael, Zhang Jinghui, Myers Jason R, Spector Logan G, Turcotte Lucie M, Chanock Stephen J, Yang Jun J, Nichols Kim E, Pui Ching-Hon, Xu Jian, Mullighan Charles G, Hudson Melissa M, Ness Kirsten K, Armstrong Gregory T, Chatterjee Nilanjan, Im Cindy, Wang Zhaoming

Abstract excerpt

BACKGROUND: Germline genetic susceptibility to pediatric acute lymphoblastic leukemia (pALL) remains incompletely characterized across the allelic spectrum, including ultrarare, high-penetrance cancer-predisposing variants (CPV). METHODS: We analyzed germline genetic data from 3,208 pALL survivors, 7,821 non-pALL survivors, and 377 noncancer controls from the St. Jude Lifetime Cohort Study and the Childhood...

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Identifiers

PMID: 42089785
DOI: 10.1158/1055-9965.EPI-26-0156
PMCID: PMC13251607

Genes

SECTM1
BRCA1
CDKN2A
IMPACT
PALB2
PTPN11
TP53

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