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Article

Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia.

Scientific reports - 23 Jun 2022

Douglas Suvi P M, Lahtinen Atte K, Koski Jessica R, Leimi Lilli, Keränen Mikko A I, Koskenvuo Minna, Heckman Caroline A, Jahnukainen Kirsi, Pitkänen Esa, Wartiovaara-Kautto Ulla, Kilpivaara Outi

Abstract excerpt

Despite recent progress in acute lymphoblastic leukemia (ALL) therapies, a significant subset of adult and pediatric ALL patients has a dismal prognosis. Better understanding of leukemogenesis and recognition of germline genetic changes may provide new tools for treating patients. Given that hematopoietic stem cell transplantation, often from a family member, is a major form of treatment in ALL, acknowledging the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35739278
DOI: 10.1038/s41598-022-14364-x
PMCID: PMC9225984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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