Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.

doi:10.1038/nature25795

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Article

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.

Nature - 15 Mar 2018

Ma Xiaotu, Liu Yu, Liu Yanling, Alexandrov Ludmil B, Edmonson Michael N, Gawad Charles, Zhou Xin, Li Yongjin, Rusch Michael C, Easton John, Huether Robert, Gonzalez-Pena Veronica, Wilkinson Mark R, Hermida Leandro C, Davis Sean, Sioson Edgar, Pounds Stanley, Cao Xueyuan, Ries Rhonda E, Wang Zhaoming, Chen Xiang, Dong Li, Diskin Sharon J, Smith Malcolm A, Guidry Auvil Jaime M, Meltzer Paul S, Lau Ching C, Perlman Elizabeth J, Maris John M, Meshinchi Soheil, Hunger Stephen P, Gerhard Daniela S, Zhang Jinghui

Abstract excerpt

Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages. Pan-cancer analyses have been performed for adult but not paediatric cancers, which commonly occur in developing mesodermic rather than adult epithelial tissues. Here we present a pan-cancer...

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PMID: 29489755
DOI: 10.1038/nature25795
PMCID: PMC5854542

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