The Role of "Adult-Onset" Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review.

doi:10.1002/1545-5017.70465

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The Role of "Adult-Onset" Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review.

Pediatric blood & cancer - 1 Sept 2026

Rozo Maria, Bornhorst Miriam A, Waanders Angela J, Zarnegar-Lumley Sara, Koppayi Ashwin Lakshman, Godley Lucy A

Abstract excerpt

Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as "adult-onset" CPGs (aoCPGs). Because next-generation sequencing (NGS)-based molecular tumor profiling, whole genome sequencing (WGS), and whole exome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Child
Share to Genetic Predisposition to Disease
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasms

Source

Open in PubMed

Identifiers

PMID: 42527977
DOI: 10.1002/1545-5017.70465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.