Article

The landscape of structural variation in pediatric cancer

2025-04-26

Abstract excerpt

Structural variants (SVs) account for over 60% of the driver variants in pediatric cancer, and in many cases act as the cancer initiating event. To study SVs from a pan-cancer perspective, we analyzed 1,616 pediatric cancer genomes in 16 major cancer types of hematological malignancies (n = 908), brain tumors (n = 183), and solid tumors (n = 525) and compared their profiles to those of 2,203 adult cancers. The SV...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc320952-d0e9-5f51-84f3-972d09c4c59f
DOI: 10.1101/2025.04.24.650284

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The landscape of structural variation in pediatric cancerDOI 10.1101/2025.04.24.650284Read

Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.Semantic proximity Read

Somatic structural variation signatures in pediatric brain tumorsSemantic proximity Read

Somatic structural variation signatures in pediatric brain tumors.Semantic proximity Read

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.Semantic proximity Read

The genomic landscape of pediatric cancers: Implications for diagnosis and treatmentSemantic proximity Read

Comprehensive analysis of mutational signatures in pediatric cancersSemantic proximity Read

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumorsSemantic proximity Read

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.Semantic proximity Read

Rare germline structural variants increase risk for pediatric solid tumorsSemantic proximity Read

Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumorsSemantic proximity Read

Rare germline structural variants increase risk for pediatric solid tumors.Semantic proximity Read

Structural Variation in Cancer: Role, Prevalence, and Mechanisms.Semantic proximity Read