Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inherited genetic variation in childhood acute lymphoblastic leukemia.

Blood - 25 Jun 2015

Moriyama Takaya, Relling Mary V, Yang Jun J

Abstract excerpt

Although somatically acquired genomic alterations have long been recognized as the hallmarks of acute lymphoblastic leukemia (ALL), the last decade has shown that inherited genetic variations (germline) are important determinants of interpatient variability in ALL susceptibility, drug response, and toxicities of ALL therapy. In particular, unbiased genome-wide association studies have identified germline variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Childhood Cancer Survivors' Quality of Life

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TPMT gene

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 25999454
DOI: 10.1182/blood-2014-12-580001
PMCID: PMC4481591

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherited genetic variation in childhood acute lymphoblastic leukemia.PMID 25999454Read ↗

Somatic and germline genomics in paediatric acute lymphoblastic leukaemia.Semantic proximity Read ↗

Genetic predisposition to acute lymphoblastic leukemia: Overview on behalf of the I-BFM ALL Host Genetic Variation Working Group.Semantic proximity Read ↗

Recent advances in genetic predisposition to pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Investigating the causes of childhood acute lymphoblastic leukemia through mutational epidemiology.Semantic proximity Read ↗

Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia.Semantic proximity Read ↗

The functional role of inherited CDKN2A variants in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Genomic characterization of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Childhood acute lymphoblastic leukemia: Integrating genomics into therapy.Semantic proximity Read ↗

Current evidence for an inherited genetic basis of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Genetic abnormalities associated with acute lymphoblastic leukemia.Semantic proximity Read ↗

Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy.Semantic proximity Read ↗

Pharmacogenetics in acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.